La Casa de Estudillo was completed in 1829 by commander of the presidio of San Diego, Captain Jose Maria de Estudillo. He only lived in the house for a year before he died, and the house passed on to his son, Jose Antonio Estudillo. He served in many positions under Mexican and then Spanish rule. His family lived there until 1887. It was restored in 1910 and donated to the state. The house is currently operated as a museum.
Employees have reported seeing faces appear in mirrors when there was no one else in the room. There are reports of shadow apparitions, cold spots, and flashing red lights in some of the rooms, and the apparition of a monk has been seen near the room which served as a chapel. The ghosts of La Casa de Estudillo have also played music with no discernible source.